Immunoterapy

For years, Riddell’s lab has been designing specialized receptors, CARs, that redirect T cells to destroy tumors.

“This approach has been very successful in leukemia and lymphoma that grows in bone marrow and lymph nodes but has not achieved the same success in metastatic solid tumors,” he said. “This is due both to a lack of molecules that can be targeted and to challenges in eliminating large solid tumors.”

Using new advances in protein design developed in the Baker Lab at UW, the researchers believe it is possible to engineer unique, customizable CARs that will be highly specific for DTCs and can direct T cells to kill them.

“Targeting dormant DTCs, especially those in sites like the bone marrow that are readily accessible to T cells, is an exciting application of CAR T cells and will help determine how new advances in synthetic protein design can be applied to patient therapy,” Riddell said.

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You are the reason for me to run rosetta@home. Untill I saw those posts of you I was thinking rosetta and bakerlab was nothing near folding@home. This forum, rosetta offical twitter account all are silent and thought they are not producing any valuable papers etc. Now I just switched some of my cpus from folding@home to rosetta@home at the moment.

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This forum, rosetta offical twitter account all are silent and thought they are not producing any valuable papers etc.

You have to follow IPD Twitter Account:UW Protein Design

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