Chroma learns patterns in the three-dimensional structures and amino acid sequences of proteins and protein complexes from the Protein Data Bank. By learning these patterns in a way that generalizes across natural proteins, Chroma can synthesize new protein molecules that adhere to these principles while combining them in novel ways. Importantly, Chroma can be conditioned on a set of desired structural or functional properties, such as the presence of functional structural motifs, symmetry constraints, adhering to a pre-specified shape, belonging to a domain or functional class, or even satisfying text-based descriptions