Rosetta 3.15 introduces several new protocols focused on modeling and designing small-molecule ligands and noncanonical amino acids. These include:

REvoLd (Rosetta Evolutionary Ligand) for evolutionary ligand design
RosettaAMRLD for automated Monte Carlo reaction-based ligand design
GALigandDock, which integrates cryoEM density to evaluate ligand docking
New apps and tools such as sim_cryo for cryoEM density simulation, expanded ligand motifs utilities, and a new FakeRotLib approach for NCAAs

Beyond protocols, Rosetta 3.15 adds new movers, filters, and chemistries to expand options for drug design, ligand docking, and structural modeling workflows