Rosetta and metalloprotein research?

Author	Message
Sean Kiely Send message Joined: 31 Jan 06 Posts: 65 Credit: 43,992 RAC: 0	Message 62961 - Posted: 17 Aug 2009, 20:53:26 UTC I just read an article in Nature concerning metalloproteins (proteins containing metal ions.) Does Rosetta do any work with metalloproteins or is that outside the scope of Rosetta's design? ID: 62961 · Rating: 0 · rate: / Reply Quote

Evan Send message Joined: 23 Dec 05 Posts: 268 Credit: 402,585 RAC: 0	Message 62968 - Posted: 18 Aug 2009, 9:18:00 UTC There has been quite a lot of work done with zinc. This is a link to an old message in RALPH when these work units were first introduced to us. message 4286 ID: 62968 · Rating: 0 · rate: / Reply Quote

JChojnacki Send message Joined: 17 Sep 05 Posts: 71 Credit: 10,633,777 RAC: 5,750	Message 62970 - Posted: 18 Aug 2009, 15:32:26 UTC - in response to Message 62968. There has been quite a lot of work done with zinc. This is a link to an old message in RALPH when these work units were first introduced to us. message 4286 Additional information about zinc can also be found in the sticky post: Structure prediction of zinc-binding proteins. ID: 62970 · Rating: 0 · rate: / Reply Quote

David Baker Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 17 Sep 05 Posts: 705 Credit: 559,847 RAC: 0	Message 62972 - Posted: 19 Aug 2009, 6:44:00 UTC we are doing a lot with metals these days: both predicting structures of metal containing proteins (this is interesting because proteins tend to organize around metals, and we had to extend Rosetta to describe this), and designing enzyme catalysts that use a metal to help break chemical bonds. ID: 62972 · Rating: 0 · rate: / Reply Quote