BMAA, Alzheimer's, Parkinson's, and ALS
Message boards : Cafe Rosetta : BMAA, Alzheimer's, Parkinson's, and ALS
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 robertmilesSend message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807 
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A video related to research on BMAA and its possible relation to Alzheimer's, Parkinson's, and ALS: Secrets to Alzheimer's, ALS and Parkinson's Disease: Dr. Paul Alan Cox at TEDxJacksonHole http://tedxtalks.ted.com/video/Secrets-to-Alzheimers-ALS-and-P Says that a dietary supplement called l-serine MIGHT be a suitable treatment for at least one of these. They are testing whether it is; not enough results yet to tell. A web site that MAY offer a more detailed and more technical video (in English) on this: http://www.ur.se/Produkter/170138-UR-Samtiden-Miljo-och-framtidstro-Klimatet-och-halsan The instructions are in Swedish, though, so it's hard to tell if you can't read Swedish. |
rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
A video related to research on BMAA and its possible relation to Alzheimer's, Parkinson's, and ALS: http://www.ur.se/Produkter/170138-UR-Samtiden-Miljo-och-framtidstro-Klimatet-och-halsan http://tedxtalks.ted.com/video/Secrets-to-Alzheimers-ALS-and-P |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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A web site mentioning something that helps control the excess iron in the brain that occurs during Parkinson's disease: 2009-08-parkinson-disease-iron It's an iron-binding protein, so adding iron to the metal ions your software can link to proteins might help investigate Parkinson's disease also. |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Do any fungi produce BMAA? A new study connects Alzheimer's disease with a brain fungus <http://www.dailykos.com/story/2015/10/27/1441252/-A-new-study-connects-Alzheimer-s-disease-with-a-brain-fungus> |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Most of the site is accessible only from within Sweden. However, I was able to access enough to use Google Translate to get this summary: Paul Alan Cox, professor and director of the Institute for ethnomedicine in Wyoming, USA, shows one of the winners of the Earth's climate is getting warmer, namely the cyanobacteria. They like the heat, increasing in number and produce a neurotoxin called BMAA. This toxin is now suspected in turn cause including ALS and Alzheimer's disease in humans. Preferring Gets Title: Climate change, biodiversity and human health. Moderator: Henrik Ekman. Organizers: King Carl XVI Gustaf's 50th årsfond for Science, Technology and Environment, Royal. Agriculture and Forestry Academy, Royal Academy. Sciences, Engineering Sciences and the Confederation of Swedish Enterprise. From the arrangement Faith in the Future held in the Bernadotte Library at the Royal Palace March 22, 2012. Some articles that seem relevant (some appear to be research papers, some written for the public): Algae bloom toxin linked to Alzheimer's, other diseases http://www.cbsnews.com/news/algae-bloom-toxin-linked-to-alzheimers-and-other-neurodegenerative-diseases/ Secrets to Alzheimer's, ALS and Parkinson's Disease: Dr. Paul Alan Cox at TEDxJacksonHole https://www.youtube.com/watch?v=7jWi6WQQ9wo You can skip the ad before the video. New research offers hope for Alzheimer’s patients http://www.jhnewsandguide.com/news/health/new-research-offers-hope-for-alzheimer-s-patients/article_ab9326a2-ddaf-53bf-84cd-9fe814f3fb19.html The Emerging Science of BMAA: Do Cyanobacteria Contribute to Neurodegenerative Disease? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295368/ Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain http://rspb.royalsocietypublishing.org/content/283/1823/20152397 Research points to pond scum connection for ALS, Alzheimer’s diseases http://www.mypalmbeachpost.com/lifestyles/health/research-points-pond-scum-connection-for-als-alzheimer-diseases/O23lvN1VdNFoxOBPGt86hI/ Could environmental toxins trigger amyloid plaques in the brain? An interview with Dr Paul Alan Cox http://www.news-medical.net/news/20160314/Could-environmental-toxins-trigger-amyloid-plaques-in-the-brain-An-interview-with-Dr-Paul-Alan-Cox.aspx Environmental toxin linked to dementia, study shows https://www.washingtonpost.com/local/social-issues/environmental-toxin-linked-to-dementia-study-shows/2016/01/19/e78b7ac4-bef7-11e5-83d4-42e3bceea902_story.html?utm_term=.907f2b7cabaa Tangles and Toxins: An interview with Dr Paul Alan Cox http://www.hurondigitalpathology.com/resource/tangles-toxins-interview-dr-paul-alan-cox/ Mentions vervet monkeys as an animal model for such research. Does not appear to mention whether l-serine has been tried enough on humans to decide whether it offers humans any help with these conditions. |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Alzheimer's researchers find molecule that delays onset of disease Guardian.article Could the Rosetta@Home researchers interested in Alzheimer's check whether the 3D structure of the Brichos molecule is ready to use, and if not, add it to the list of molecules for structure investigation? |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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I just found that Brichos is a family of molecules, not just one. Some articles that may name the most important type: (title will not copy and paste) BCJ article Molecular inhibitor breaks cycle that leads to Alzheimer’s Molecular inhibitor breaks cycle that leads to Alzheimer’s High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C. High-resolution structure of a BRICHOS domain BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide* BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide Molecule could protect against Alzheimer's disease Molecule could protect against Alzheimer's disease Brichos protein may prevent brain damage in Alzheimer’s Brichos protein may prevent brain damage in Alzheimer’s |
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[VENETO] boboviz Send message Joined: 1 Dec 05 Posts: 1994 Credit: 9,623,704 RAC: 9,591 
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rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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The recent research on BMAA gave conflicting evidence on whether BMAA is involved in these neurological conditions or not. Could this mean that they are actually caused by something so similar to BMAA than some of the methods use to measure BMAA can tell the two apart, and some of the other methods cannot? beta-Methylamino-L-alanine https://en.wikipedia.org/wiki/Beta-Methylamino-L-alanine beta-N-Methylamino-L-alanine (compound) https://pubchem.ncbi.nlm.nih.gov/compound/beta-N-Methylamino-L-alanine#section=Related-Records β-methylamino-L-alanine (BMAA) is not found in the brains of patients with confirmed Alzheimer’s disease https://www.nature.com/articles/srep36363 Are Toxins in Seafood Causing ALS, Alzheimer's, and Parkinson's? https://www.discovermagazine.com/mind/are-toxins-in-seafood-causing-als-alzheimers-and-parkinsons β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007225 Human Scalp Hair as an Indicator of Exposure to the Environmental Toxin β-N-Methylamino-l-alanine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793101/ β-N-Methylamino-l-alanine (BMAA) Toxicity Is Gender and Exposure-Age Dependent in Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793103/ Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice. https://europepmc.org/article/med/16808967 Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model https://www.hindawi.com/journals/jt/2015/739746/ The environmental neurotoxin β-N-methylamino-l-alanine (l-BMAA) is deposited into birds' eggs https://www.sciencedirect.com/science/article/abs/pii/S014765131730605X Researchers conduct metabolite analysis of ALS patient blood plasma https://www.eurekalert.org/pub_releases/2020-05/ncsu-rcm052920.php Metabolite Analysis of ALS Patient Blood Plasma Could Reveal, Rule Out, Possible Biomarkers for Disease https://news.ncsu.edu/2020/05/als-plasma-biomarker/ Occurrence of β-N-methylamino-l-alanine (BMAA) and Isomers in Aquatic Environments and Aquatic Food Sources for Humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848184/ Blue-green algae linked to ALS in UM study, but researchers also found promising treatment https://www.miamiherald.com/news/health-care/article240701886.html |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know? https://pubmed.ncbi.nlm.nih.gov/24662480/ |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Duplicate |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Also under consideration for Alzheimer's. Experimental drug for ALS, dreamed up in a dorm room, offers patients glimmer of hope https://www.statnews.com/2020/09/02/experimental-drug-for-als-dreamed-up-in-a-dorm-room-offers-patients-glimmer-of-hope/ |
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robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,281,662 RAC: 1,807
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Also Parkinson's. Air pollution particles in young brains linked to Alzheimer's damage https://www.theguardian.com/environment/2020/oct/06/air-pollution-particles-in-young-brains-linked-to-alzheimers-damage |
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rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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BMAA, Alzheimer's, Parkinson's, and ALS
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